From the local to the national level and around the world, governments are looking for new ways to address the complex challenges they are facing, such as climate change, migration, or inequality. In this context, systems innovation has enormous potential to inform new ways of mobilizing public sector capacity that go beyond bureaucratic and siloed interventions. From Sweden to the UK to Catalunya, from portfolios to ecosystems, systemic approaches are starting to gain traction. In this panel, we will explore how systems thinking can help the public sector address complex challenges. We will draw upon the experience and insights of Mariana Mirabile of the OECD Environment, Alex Fleming from the Policy Lab UK and Georgia Cameron the Policy Innovation Lead at Dark Matter Labs with the panel moderated by Nadim Choucair.